Cardiovascular System (CDPM330)

This course covers normal and abnormal processes in the cardiovascular system and introduces clinical approaches to diagnosis and treatment of the most prevalent cardiovascular diseases.

Credit Hours : 7

Course Learning Outcomes

1. Demonstrate Capability To Communicate Professionally And Learn In Collaborative Groups.
2. Demonstrate Life-Long Learning Skills For Personal And Professional Growth And Development.
3. Describe The Epidemiology, Etiology, Pathogenesis And Management Of Metabolic And Regulatory Disorders Of Cardiovascular System.
4. Describe The Pathology, Pathophysiology, Radiological Findings And Management Of Heart Failure.
5. Discuss The Pathogenesis And Management Of Conditions Associated With Abnormal Arterial, Venous And Lymphatic Circulation.
6. Explain The Development Of Congenital Heart Disease.
7. Outline The Etiology, Pathology And Management Of Acquired Heart Diseases.
8. Outline The Pathophysiology, Electrocardiographic Signs And Pharmacological Management Of Cardiac Arrhythmias.

Pharmacology (PHAM225)

This course covers basic pharmacology topics such as the nature of drugs, the different forms of drugs, the processes and the factors that influence their absorption, transportation, effectiveness, and elimination. Students will be able to relate the normal and abnormal processes of the autonomic nervous system and the pharmacological agents which forms the bases for the therapy for the autonomic system disorders.

Credit Hours : 3

Course Learning Outcomes

1. Describe The Concept Of Pharmacogenomics, Adverse Drug Reactions And Drug Metabolism, Disposition In Pediatric And Geriatric Subjects.
2. Describe The Concept Of Pharmacokinetics And Pharmacodynamic Actions Of Drug In The Human Body.
3. Describe The Fundamental Concepts Of Clinical Pharmacology And The Process Of Drug Development.
4. Describe The Regulatory Aspects Of Drug Approval.
5. Describe The Role Of Autonomic System Pharmacology In Health And Disease.
6. Describe The Role Of Neurotransmitters In Health And Disease Conditions.

General Systemic Pharmacology (PHTX601)

This course is designed to teach graduate students the effects of drugs on different organ systems. The drugs acting on major organ systems will be reviewed (the autonomic nervous system and the cardio-vascular, respiratory, kidney, endocrine, gastrointestinal, neuromuscular transmision, antimicrobials and central nervous systems). The course will deal with understanding the molecular basis for the actions of drugs and the characteristics of interactions between drug molecules and those of the substrates of drug action in the cell. This course will be in a seminar format as well as computer based practical programs.

Credit Hours : 2

Course Learning Outcomes

1. Analyze The Pharmacology Of Histamine, Serotonin And Nitric Oxide, The Eicosanoids Like Prostaglandins, Thromboxanes, Leukotrienes, And Related Compounds.
2. Categorize The Mechanism Of Action Of Drugs Affecting The Hypothalamic, The Pituitary, The Adrenocortical, The Gonadal, The Thyroid, The Pancreas And The Parathyroid Hormones As Well As Their Clinical Relevance.
3. Categorize The Molecular Mechanisms And The Clinical Applications Of Drugs Used In Pain (Opioids, Nsaids, Paracetamol, Celecoxib), Movement Disorders, The Uterus, Antimicrobials And Cancer.
4. Categorize The Molecular Mechanisms Of Action And The Clinical Applications And Side Effects Of Drugs Used In The Cns, Neuromuscular Transmission, Asthma And The Gastrointestinal Tract.
5. Classify The Mechanism Of Action, Clinical Indications & Contra-Indications Of The Different Sympathomimetics, ? And- ?-Adrenoceptor, And Parasympathomimetics.
6. Explain The Molecular Mechanisms Of Action And The Clinical Applications And Side Effects Of Drugs Used In Cardiovascular And Blood Disorders.

Molecular Mechanism of Drug Action (PHTX602)

This course is designed to teach graduate students general principles of drug actions in the biological systems. The topics are designed to cover most of the major biological mechanisms involved in drug actions. There will also be opportunity to understand current approaches to the principles that dictate interactions of drugs with biological systems.

Credit Hours : 2

Course Learning Outcomes

1. Demonstrate a broad knowledge of molecular mechanisms of modern pharmacology, from the molecular basis of receptors, to the effects of drugs on whole body systems.
2. Identify the major classes of drug receptors and sites of drug action within the body.
3. Explain the principles of pharmacokinetics and pharmacodynamics and their application in drug development.
4. Describe the pharmacogenomics, drug idiosyncrasy, chemical teratogenesis, different types of drug allergies, and factors associated with drug resistance.
5. Analyze drug-response curves of drug agonists and antagonists.
6. Recognize the fundamental methods used in drug development.
7. Apply principles of molecular mechanisms on drugs with actual drug-response curves, and various PK profiles.

Neurotransmitters in Health and Diseases (PHTX603)

This course is devoted to exploring the biosynthesis, inactivation, receptors, and signaling mechanisms of neurotransmitters and chemical mediators including GABA, glutamate, acetylcholine, catecholamines, purines, peptides, prostaglandins, and histamines. In brief, the molecular and cellular aspects of receptor mechanisms as well as signaling pathways, and effector systems will be discussed. The teaching format includes Seminars and discussions.

Credit Hours : 2

Course Learning Outcomes

1. Describe The Receptors Signalling And Synaptic Transmission
2. Describe The Cellular And Molecular Foundations Of Neuropharmacology
3. Describe The Pathophysiological And Pharmacological Relevance Of Amino Acid Transmitters In Neruological Pathologies
4. Describe The Pathophysiological And Pharmacological Relevance Of Catecholamines, Biogenic Amines And Neuropeptides In Neurological Pathologies
5. Describe The Pharmaco-Therapeutic Implications Of Neurotransmitters In Psychiatric Diseases
6. Present The Analytical Techniques Used In The Study Of Neuropharmacology And Biology

Molecular Principles of Organ Toxicity (PHTX604)

This course is designed to teach graduate students the mechanisms involved in the actions of drugs and toxins on the target organs. The course will focus on molecular mechanism of chemically-induced toxicity to specific organs in the mammalian species. It describes the principles of cellular and molecular mechanisms of organ system toxicology with emphasis on developmental toxicology, carcinogenesis, immune toxicity, renal toxicity, hepatic toxicity and neurotoxicity.The effects of toxins on respiratory, blood, cardiac, skin and eyes at the cellular level will also be addressed in this course. Various factors affecting toxicity to each particular organ will be studied.

Credit Hours : 2

Course Learning Outcomes

1. Describe The Basic Principles Involved In Toxicokinetics Including Xenobiotics Absorption, Distribution, Metabilism And Elimination
2. Describe The Mechanims Of Hematological Toxicity, The Approaches To Toxins Hemodialysis And To Delayed Toxins Absorption
3. Describe The Various Agents That Cause Liver, Kidney, Heart, Lung, Cns, Skin And Endocrine Toxicity And Explain Their Cellular And Molecular Mechanisms Of Action
4. Explain The Mechanisms Of Toxicity And Principles Of Toxicology Including Impact Of The Dose, The Route And The Duration Of Exposure To A Toxicant And The Animal Models Used In Toxicological Studies
5. Explain The Molecular Mechanisms Of Developmental Toxicology, Carcinogenesis, Targeted Anti-Cancer Therapies, The Off Target Effects And Principles Of Rna Interference, Oxidative Stress, Cell Cycle And Cell Death
6. Prepare A Presentation On A Topic Related To The Course

Advanced Pharmacotherapy 1 (PHTX607)

Advanced Pharmacotherapy courses are designed to provide students with advanced knowledge in clinical therapeutics. Students will gain the necessary skills and knowledge required to optimize patients’ treatment and design an evidence-based individualized pharmacotherapeutic plan. The course will discuss treatment of choices, adding and adjusting medications and doses. Goals of treatment and monitoring strategies, drug interactions, and adverse drug reactions will be also discussed for each disease and medications. Pharmacotherapy 1 will focus on cardiovascular diseases (Hypertension, dyslipidaemia, ischemic heart disease, heart failure, venous thromboembolism, Peripheral artery disease, acute coronary syndrome, atrial fibrillation and stroke).

Credit Hours : 3

Course Learning Outcomes

1. Identify aetiology, risk factors, pathophysiology, signs, symptoms and diagnostic criteria of cardiovascular diseases (Hypertension, dyslipidaemia, ischemic heart disease, heart failure, venous thromboembolism, Peripheral artery disease, acute coronary syndrome, atrial fibrillation and stroke).
2. Contrast the mechanisms of action, pharmacokinetic/pharmacodynamics properties, indications, side effects, dosage regimens, contraindications and interactions for pharmacotherapeutic options in cardiovascular diseases.
3. Design an individualized pharmacotherapeutic regimen for patients with cardiovascular diseases
4. Analyse and monitor patient treatment outcomes for efficacy, safety, adverse drug reactions, and drug interactions and redesign/adjust pharmacotherapeutic regimens accordingly to optimize health outcomes in patients with cardiovascular diseases.
5. Evaluate patient adherence to medications and counsel patients appropriately on their treatment.

Advanced Pharmacotherapy 2 (PHTX608)

Advanced Pharmacotherapy courses are designed to provide students with advanced knowledge in clinical therapeutics. Students will gain the necessary skills and knowledge required to optimize patients’ treatment and design an evidence-based individualized pharmacotherapeutic plan. The course will discuss treatment of choices, adding and adjusting medications and doses. Goals of treatment and monitoring strategies, drug interactions, and adverse drug reactions will be also discussed for each disease and medications. Pharmacotherapy 2 will focus on Endocrine and Renal diseases (Diabetes Mellitus type I&II, Thyroid Disorders, Adrenal Gland Disorders, Acid-Base Disorders, Acute Kidney injury, Chronic Kidney Disease).

Credit Hours : 3

Course Learning Outcomes

1. Identify aetiology, risk factors, pathophysiology, signs, symptoms and diagnostic criteria of Endocrine and Renal diseases (Diabetes Mellitus type I&II, Thyroid Disorders, Adrenal Gland Disorders, Acid-Base Disorders, Acute Kidney injury, Chronic Kidney Disease).
2. Contrast the mechanisms of action, pharmacokinetic/pharmacodynamics properties, indications, side effects, dosage regimens, contraindications and interactions for pharmacotherapeutic options in Endocrine and Renal diseases.
3. Design an individualized pharmacotherapeutic regimen for patients with Endocrine and Renal diseases.
4. Analyse and monitor patient treatment outcomes for efficacy, safety, adverse drug reactions, and drug interactions and redesign/adjust pharmacotherapeutic regimens accordingly to optimize health outcomes in patients with Endocrine and Renal diseases.
5. Evaluate patient adherence to medications and counsel patients appropriately on their treatment.

Advanced Pharmacotherapy 3 (PHTX609)

Advanced Pharmacotherapy courses are designed to provide students with advanced knowledge in clinical therapeutics. Students will gain the necessary skills and knowledge required to optimize patients’ treatment and design an evidence-based individualized pharmacotherapeutic plan. The course will discuss the treatment of choices, adding and adjusting medications and doses. The goals of treatment and monitoring strategies, drug interactions, and adverse drug reactions will be also discussed for each disease and medication. Pharmacotherapy 3 will focus on Respiratory, Gastrointestinal, Rheumatology, and Bone Diseases (Asthma, Chronic Obstructive Pulmonary Disease (COPD), Gastrointestinal Reflux Disease (GERD), Peptic Ulcer, Inflammatory Bowel Diseases (IBDs), Portal Hypertension and Liver Cirrhosis, Osteoarthritis, Rheumatoid Arthritis, and Osteoporosis).

Credit Hours : 2

Course Learning Outcomes

1. Identify aetiology, risk factors, pathophysiology, signs, symptoms and diagnostic criteria of Respiratory, Gastrointestinal, Rheumatology, and Bone Diseases (Asthma, Chronic Obstructive Pulmonary Disease, Gastrointestinal Reflux Disease (GERD), Peptic Ulcer, Inflammatory Bowel Diseases, Portal Hypertension and Liver Cirrhosis, Osteoarthritis, Rheumatoid Arthritis, and Osteoporosis).
2. Contrast the mechanisms of action, pharmacokinetic/pharmacodynamics properties, indications, side effects, dosage regimens, contraindications and interactions for pharmacotherapeutic options in Respiratory, Gastrointestinal, Rheumatology, and Bone Diseases.
3. Design an individualized pharmacotherapeutic regimen for patients with Respiratory, Gastrointestinal, Rheumatology, and Bone Diseases.
4. Analyse and monitor patient treatment outcomes for efficacy, safety, adverse drug reactions, and drug interactions and redesign/adjust pharmacotherapeutic regimens accordingly to optimize health outcomes in patients with Respiratory, Gastrointestinal, Rheumatology, and Bone Diseases.
5. Evaluate patient adherence to medications and counsel patients appropriately on their treatment.

Advanced Pharmacotherapy 4 (PHTX610)

Advanced Pharmacotherapy courses are designed to provide students with advanced knowledge in clinical therapeutics. Students will gain the necessary skills and knowledge required to optimize patients’ treatment and design an evidence-based individualized pharmacotherapeutic plan. The course will discuss treatment of choices, adding and adjusting medications and doses. Goals of treatment and monitoring strategies, drug interactions, and adverse drug reactions will be also discussed for each disease and medications. Pharmacotherapy 4 will focus on Infectious diseases and Critical Care Conditions (CNS infections, upper and lower Respiratory Infections, urinary tract infections, sepsis and septic shock, surgical prophylaxis, invasive fungal infections, skin and soft tissues infections, Clostridium difficile infection).

Credit Hours : 3

Course Learning Outcomes

1. Identify aetiology, risk factors, pathophysiology, signs, symptoms and diagnostic criteria of Infectious diseases and Critical Care Conditions (CNS infections, upper and lower Respiratory Infections, urinary tract infections, sepsis and septic shock, surgical prophylaxis, invasive fungal infections, skin and soft tissues infections, Clostridium difficile infection).
2. Contrast the mechanisms of action, pharmacokinetic/pharmacodynamics properties, indications, side effects, dosage regimens, contraindications and interactions for pharmacotherapeutic options in Infectious diseases and Critical Care.
3. Design an individualized Pharmacotherapeutic regimen for patients with Infectious diseases and Critical Care.
4. Analyse and monitor patient treatment outcomes for efficacy, safety, adverse drug reactions, and drug interactions and redesign/adjust Pharmacotherapeutic regimens accordingly to optimize health outcomes in patients with Infectious diseases and Critical Care Conditions.
5. Evaluate patient adherence to medications and counsel patients appropriately on their treatment.
6. Demonstrate knowledge of the principles and applications of antimicrobial stewardship program.

Medication Management and Pharmaceutical Care (PHTX612)

This course introduces the student to their professional and clinical responsibilities as a pharmacist. The course will also provide the students with a systematic approach to patient-centred pharmaceutical care that will be applied and practiced throughout the curriculum and clinical clerkship. Topics covered include pharmaceutical care, ethical principles, providing drug information, communication skills, evidence-based medicine, collecting patient history, designing pharmacotherapy care plan, monitoring and adjusting treatment, and communicating recommendations to physicians.

Credit Hours : 3

Course Learning Outcomes

1. Identify the sources and collect the essential elements of a patient database.
2. Analyze patient data to identify and manage medication related problems.
3. Design an individualized pharmacotherapy care and monitoring plan.
4. Communicate effectively with patients, physicians, and other health care professionals.
5. Apply the principles of drug information and evidence-based medicine in patient care.
6. Recognize the ethical principles involved in making decisions in the clinical care of patients.

Advanced Pharmacy Practice Experience 4: Ambulatory Care (PHTX613)

This 4 Weeks internship will prepare interns to understand various disease states and pharmacotherapy as they relate to the management of patients in the ambulatory care setting. Intern will develop the necessary skills in optimizing pharmaceutical care plan including obtaining medication histories, assessing the appropriateness of medication regimens and protocols, counseling patients, monitoring therapies, and providing appropriate drug information to both patients and health-care providers.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the ambulatory care setting to assure safe and effective pharmacotherapy and optimize therapeutic outcomes.
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence.
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management.
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in the ambulatory care setting.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.

Advanced Pharmacy Practice Experience 2: General Internal Medicine 1 (PHTX614)

This 2*4 Weeks internship will prepare the interns to become familiar with the etiology, pathophysiology, and treatment (drug and non-drug) of disease states commonly found in the adult internal medicine patients. Intern will be able to develop skills in evaluating patient data for providing pharmaceutical care and optimal drug therapy, identifying drug-therapy related problems, and developing rational drug therapy recommendations for adult internal medicine patients. In addition, they will be able develop a basic understanding of the various diagnostic and monitoring techniques utilized in internal medicine patients.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX608 with a minimum grade D
• PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the adult internal medicine patients to assure safe and effective pharmacotherapy and optimize therapeutic outcomes.
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence.
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management.
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in internal medicine patients.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.

Advanced Pharmacy Practice Experience 9: Adult Oncology (PHTX616)

This 4 Weeks internship will prepare interns to become familiar with the etiology, pathophysiology, and treatment of disease states commonly found in oncology patients. Intern will be able to provide supportive care and to develop a pharmaceutical care plan and learn the process of identifying and solving drug related problems in oncology patients.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX608 with a minimum grade D
• PHTX609 with a minimum grade D
• PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the hematological and solid tumors to assure safe and effective pharmacotherapy and optimize therapeutic outcomes.
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan and cancer related supportive care plan that are based on the best available evidence.
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management.
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in oncology patients.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.
7. Recognize the process of preparing of chemotherapy and Intravenous admixtures.

Advanced Pharmacy Practice Experience 5: Infectious Diseases (PHTX618)

This 4 Weeks internship will prepare interns to become familiar with the etiology, pathophysiology, and treatment (drug and non-drug) of various infectious disease states. Interns should be able to develop the skills to suggest the optimum pharmaceutical care plan and learn the process of identifying and solving drug related problems to patients with certain infectious diseases. Interns will also learn the principles and develop the skills necessary for the application of antimicrobial stewardship program.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX608 with a minimum grade D
• PHTX609 with a minimum grade D
• PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the infectious diseases patients to assure safe and effective pharmacotherapy and optimize therapeutic outcomes while practicing antimicrobial stewardship.
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence.
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management.
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in infectious diseases patients.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.
7. Demonstrate understanding of the alterations in pharmacokinetics/pharmacodynamics that effect antimicrobial drug therapy and apply this understanding to the bedside care of patients with complicated infectious diseases.

Advances in Pharmacology (PHTX619)

This course will provide students the chance to rotate through the laboratory of a potential supervisor to learn about the various projects in progress in that laboratory with emphasis on acquainting themselves with the type of research work and techniques being used. Regular attendance (one hour per week) and active participation of the student in observing and learning about these projects is of great importance. The students should study the literature provided by their respective supervisors and familiarize themselves with the research activities being carried out in the laboratory chosen by them.

Credit Hours : 1

Advanced Pharmacy Practice Experience 7: General Pediatric (PHTX620)

This 4 Weeks internship will prepare interns to develop a basic understanding of disease states and conditions commonly seen in the pediatric and neonatal patient. Emphasis will be placed on the therapeutic management of pediatric patients and the unique pharmacological/pharmaceutical requirements of these patients. The role of the clinical pharmacist in the selection and monitoring of drug use in pediatric patients will be emphasized to develop a pharmaceutical care plan and learn the process of identifying and solving drug related problems among neonatal and pediatric patients.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX608 with a minimum grade D
• PHTX631 with a minimum grade DPHTX609 with a minimum grade D
• PHTX610 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the pediatric patients to assure safe and effective pharmacotherapy and optimize therapeutic outcomes
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in pediatric patients.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.
7. Identify current range of doses and dose calculation for commonly used medications and recognize various diagnostic and monitoring techniques used in the pediatric population

Advanced Pharmacy Practice Experience 8: Critical Care Medicine (PHTX621)

This 4 Weeks internship will prepare interns to become familiar with the etiology, pathophysiology, and treatment (drug and non-drug) of disease states commonly found in critically ill patients at the intensive care unit (ICU) and critical care unit (CCU). Intern will be able to develop a pharmaceutical care plan and learn the process of identifying and solving drug related problems to patients in the ICU and CCU.

Credit Hours : 4

Prerequisites

• PHTX612PHTX607PHTX608PHTX609PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the critically ill patients to assure safe and effective pharmacotherapy and optimize therapeutic outcomes.
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence.
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management.
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in critically ill patients.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.
7. Demonstrate understanding of the alterations in pharmacokinetics/pharmacodynamics that effect drug therapy in both ICU and CCU and to apply this understanding to the bedside care of critically ill patients.

Research Project 1 (PHTX623)

This course is intended to guide the student in the selection, preparation, and the ethical form submission of the research proposal. After the research proposal is prepared, submitted and approved by the ethical committee, the student will continue the project in the (Research project 2). The latter is the actual conduction of the designated research project where the student collects, analyses, and prepare the research report. The student has to conclude the proposal section successfully before moving to conducting the actual research. Research projects suggested by faculty members will be announced to the students at the beginning of each fall semester. Two students will be assigned to each project and supervised by a faculty member. Research project guideline and timeline are attached in the Appendix.

Credit Hours : 1

Course Learning Outcomes

1. Search for references in credible and relevant electronic and online search engines.
2. Analyze data from published literature in preparing a research proposal.
3. Design appropriate research methodology and statistical analysis
4. Demonstrate scientific writing skills when preparing the research proposal.
5. Cite literature in the research proposal appropriately avoiding plagiarism.
6. Follow all ethical standards in preparing the research protocol and its designed processes.

Modern Medicinal Chemistry and Drug Design (PHTX624)

A broad variety of medicinal chemistry approaches can be used for the identification of hits, generation of leads, as well as to accelerate the development of high quality drug candidates. Structure-based drug design (SBDD) methods are becoming increasingly powerful, versatile and more widely used. This course demonstrates current developments in structure-based virtual screening and receptor-based pharmacophores, highlighting achievements as well as pharmacodynamics and pharmacokinetic challenges, along with the value of structure-based lead optimization, with emphasis on recent examples of successful applications for the identification of novel active compounds.

Credit Hours : 1

Course Learning Outcomes

1. Describe Successful Stories In Medicinal Chemistry & Drug Design Related To Countering Drug Resistance & Drug Tolerance And Its Implication In Generics With Focus On The Present And Future Face Of Drug Discovery
2. Explain The Importance Of Structure-Activity Relationship For Scaffold Selection And Design
3. Explain The Medicinal Chemistry Rationale Behind Bioisosteric Replacement, Structural Mimicry And Pro-Drug Design For Improved Adme Properties
4. Explain The Role Of Medicinal Chemistry In Understanding The Rationale Of Drug Design And Lead Compound Optimization
5. Prepare A Presentation On The Topic Related To Drug Design And Development

Advanced Pharmacy Practice Experience 6: General Surgery (PHTX626)

The Surgery rotation is a 4 Weeks, elective, experientially oriented rotation where the Pharm-D student will be exposed to medication management in the surgical care setting. This will include but will not be limited to peri-operative medication management, antimicrobial surgical prophylaxis, deep venous thrombosis prophylaxis and the ordering and monitoring of total parenteral nutrition hospital-wide.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX608 with a minimum grade D
• PHTX609 with a minimum grade D
• PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the general surgery setting to assure safe and effective pharmacotherapy and optimize therapeutic outcomes
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in the general surgery setting.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.
7. Identify the major issues of the peri-operative setting and appropriate pharmacotherapy to various peri and post-operative conditions including surgical infections prophylaxis, anesthesia, sedation, peri- and post-operative pain control, neuromuscular blockage, and post-operative nausea and vomiting.

Advanced Pharmacy Practice Experience 3: General Internal Medicine 2 (PHTX627)

This 2*4 Weeks internship will prepare interns to become familiar with the etiology, pathophysiology, and treatment (drug and non-drug) of disease states commonly found in the adult internal medicine patients. Intern will be able to develop skills in evaluating patient data for providing pharmaceutical care and optimal drug therapy, identifying drug-therapy related problems, and developing rational drug therapy recommendations for adult internal medicine patients. In addition, they will be able develop a basic understanding of the various diagnostic and monitoring techniques utilized in internal medicine patients.

Credit Hours : 4

Prerequisites

• PHTX612 with a minimum grade D
• PHTX607 with a minimum grade D
• PHTX608 with a minimum grade D
• PHTX609 with a minimum grade D
• PHTX610 with a minimum grade D
• PHTX631 with a minimum grade D

Course Learning Outcomes

1. Integrate didactic knowledge and pharmaceutical care skills of the various disease states commonly found within the adult internal medicine patients to assure safe and effective pharmacotherapy and optimize therapeutic outcomes.
2. Collect, interpret and evaluate patient information to design and optimize patient pharmacotherapy plan that is based on the best available evidence.
3. Manage the drug regimen by monitoring and assessing the patient and/or patient information, collaborating with other health care professionals, and providing patient education.
4. Demonstrate effective and appropriate communication with other health care professionals, and patients regarding medication management.
5. Retrieve, evaluate, and apply evidence-based medical literature related to patient care and problem solving in internal medicine patients.
6. Demonstrate leadership qualities, professional and ethical behavior while working with other health care professionals, and providing patient centered care.

Advanced Pharmacotherapy 5 (PHTX631)

Advanced Pharmacotherapy courses are designed to provide students with advanced knowledge in clinical therapeutics. Students will gain the necessary skills and knowledge required to optimize patients’ treatment and design an evidence-based individualized pharmacotherapeutic plan. The course will discuss treatment of choices, adding and adjusting medications and doses. Goals of treatment and monitoring strategies, drug interactions, and adverse drug reactions will be also discussed for each disease and medications. Pharmacotherapy 5 will focus on Neurological, Psychiatric, Hematological, and Oncology diseases (Anxiety, Depression, Alzheimer’s disease, Epilepsy, Attention deficit hyperactivity Disease, Parkinson disease, Schizophrenia, Haematological malignancies, Oncology Supportive Care, Breast, Colorectal, Lung Cancers).

Credit Hours : 3

Course Learning Outcomes

1. Identify aetiology, risk factors, pathophysiology, signs, symptoms and diagnostic criteria of Neurological, Psychiatric, Hematological, and Oncology diseases (Anxiety, Depression, Alzheimer’s disease, Epilepsy, Attention deficit hyperactivity Disease, Parkinson disease, Schizophrenia, Hematological Malignancies, Oncology Supportive Care, Breast, Colorectal, and Lung Cancers).
2. Contrast the mechanisms of action, pharmacokinetic/pharmacodynamics properties, indications, side effects, dosage regimens, contraindications and interactions for pharmacotherapeutic options in Neurological, Psychiatric, Hematological, and Oncology diseases.
3. Design an individualized pharmacotherapeutic regimen for patients with Neurological, Psychiatric, Haematological, and Oncology diseases.
4. Analyse and monitor patient treatment outcomes for efficacy, safety, adverse drug reactions, and drug interactions and redesign/adjust pharmacotherapeutic regimens accordingly to optimize health outcomes in patients with Neurological, Psychiatric, Hematological, and Oncology diseases
5. Evaluate patient adherence to medications and counsel patients appropriately on their treatment.

Advanced Pharmacy Practice Experience 1: Hospital Pharmacy (PHTX632)

This 4 weeks internship will prepare the interns to become familiar with variety of aspects of a hospital pharmacy in both outpatient and inpatient pharmacy settings including the prescription processing, unit dose, intravenous admixture and parenteral fluids preparation, purchasing and inventory control, quality assurance, medication reconciliation, medication use evaluation, medication safety, clinical pharmacy services, regulatory requirements of drug distribution, disposal, controlled substances, investigational medication distribution, medical literature, and others issues related to hospital pharmacy practice. In addition, this internship will allow the students to gain professional skills toward patients interviewing and counseling and develop advanced communication skills with hospital pharmacy staff and other health care professionals. Students will be given the opportunity to develop manager/leadership skills through active participations in discussions and meetings concerning ethical issues encountered in practice, health care policy, pharmacy’s quality improvement program, and participation in the design, development, and marketing of patient services.

Credit Hours : 4

Prerequisites

• PHTX607 with a minimum grade D
• PHTX612

Course Learning Outcomes

1. Recognize the workflow and become familiar with all pharmacy operations in the Hospital Pharmacy.
2. Identify the hospital’s and pharmacy department’s policies and procedures.
3. Develop collaborative professional relationships and demonstrate good communication skills with pharmacists, pharmacy technicians, pharmacy interns, medical staff, nursing staff, and other healthcare team members.
4. Demonstrate skill in the assessment and quality improvement of hospital pharmacy practice.
5. Demonstrates leadership qualities for creating and achieving shared goals.
6. Develop the necessary tools and skills for self-evaluation and assessment.

Research Project 2 (PHTX633)

This course will guide the student, through a step by step on how to conduct their research study that was approved at the end of Research project 1 course. The students are expected to collect their research data, enter data into SPSS, analyse data, write study results and discuss their research findings. At the end of this course, the students are expected to submit a final research report in the form of a manuscript. Two students will be assigned to each project and supervised by a faculty member. Research project timeline and other related documents are attached in the Appendix

Credit Hours : 1

Prerequisites

• PHTX623 with a minimum grade D
• CMPH600 with a minimum grade D

Course Learning Outcomes

1. Collect and document research finding appropriately
2. Analyze research data using basic and advanced statistics utilizing statistical software and express findings in the results section of research report.
3. Discuss research finding and cite literature
4. Draw appropriate conclusions and speculations from the research results
5. Demonstarte scientific writing skills in prparing a final reserch report in the form of manuscript
6. Follow all ethical standards while conducting the research

Advanced Clinical Pharmacokinetics (PHTX634)

This course aims to develop and integrate the advanced knowledge and skills required to apply Pharmacokinetic-Pharmacodynamic (PK-PD) concepts to calculate and formulate proper dosing regimens. Students will learn how to apply the PK-PD values in selecting and monitoring drug therapy regimens that maximize the drug efficacy and minimize the toxicity. In addition, students will learn how to use the PK-PD models and formulas appropriately to determine and select the proper therapy and dose that account for various factors such as patient’s characteristics, liver and kidney, and other organs functions, disease state, drug-food, and drug-drug interactions.

Credit Hours : 2

Course Learning Outcomes

1. Demonstrate understanding of the clinical pharmacokinetic concepts and calculation utilized for therapeutic drug monitoring in clinical settings.
2. Recognize the common disease conditions and factors that lead to alteration and changes of the pharmacokinetics properties of specific drugs.
3. Apply pharmacokinetics-pharmacodynamics concepts and principles to optimize pharmacotherapy and drug dosing for maximal efficacy and minimal toxicity.
4. Identify and manage drug dosing in cases involving significant patient pharmacokinetic variability due to physiology or disease (e.g., gender, age, body weight, pregnancy, malabsorption, organ failure, critical illness).
5. Analyze and resolve clinical cases with significant pharmacokinetics-pharmacodynamics drug interactions.